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The Extended Clearance Model


Poller, Birk; Huth, Felix; Kastrinou‐Lampou, Vlasia; Kullak‐Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2021). The Extended Clearance Model. In: Li, Albert P. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. Hoboken, New Jersey: John Wiley & Sons, 455-479.

Abstract

Cell stress perturbations in the liver are frequently the result of inhibitory insults on hepatic enzyme- and/or transporter-mediated processes involved in the disposition of bile acids and/or bilirubin. Hence, in recent years, more or less complex drug–drug interaction (DDI) prediction techniques (so-called R-value models) were derived to anticipate the overall drug-induced liver injury (DILI) risk of new chemical entities. This article aims to provide an integrated overview of our latest in-house efforts to forecast quantitatively, cell stress-based DILI predominantly by integrating principles of the extended clearance model (ECM).

Abstract

Cell stress perturbations in the liver are frequently the result of inhibitory insults on hepatic enzyme- and/or transporter-mediated processes involved in the disposition of bile acids and/or bilirubin. Hence, in recent years, more or less complex drug–drug interaction (DDI) prediction techniques (so-called R-value models) were derived to anticipate the overall drug-induced liver injury (DILI) risk of new chemical entities. This article aims to provide an integrated overview of our latest in-house efforts to forecast quantitatively, cell stress-based DILI predominantly by integrating principles of the extended clearance model (ECM).

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Other titles:Chapter 15 - The Extended Clearance Model : A Valuable Tool For Drug-Induced Liver Injury Risk Prediction
Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > General Medicine
Life Sciences > General Pharmacology, Toxicology and Pharmaceutics
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Physical Sciences > General Chemistry
Language:English
Date:4 August 2021
Deposited On:15 Nov 2022 12:27
Last Modified:21 Jun 2024 03:40
Publisher:John Wiley & Sons
ISBN:978-1-119-17084-6
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/9781119171003.ch15
Other Identification Number:Online ISBN:9781119171003
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