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Advantages of nanoscale bioactive glass as inorganic filler in alginate hydrogels for drug delivery and biofabrication


Bider, Faina; Karakaya, Emine; Mohn, Dirk; Boccaccini, Aldo R (2022). Advantages of nanoscale bioactive glass as inorganic filler in alginate hydrogels for drug delivery and biofabrication. European Journal of Materials, 2(1):33-53.

Abstract

Sodium alginate is a natural biocompatible polymer obtained from brown algae which has found numerous biomedical applications. Inorganic fillers, such as nanosized bioactive glass (nBG) particles, are well known for their outstanding properties in terms of being osteoconductive and osteoinductive and therefore finding application in bone tissue engineering. In this study, the impact of nBG particles on alginate hydrogels was investigated for applications of the composite hydrogel in biofabrication and drug delivery. The influence of nBG particles on properties such as printability, drug release ability and bioactivity (capability to form a hydroxyapatite (HAp) layer on the surface of nBG-alginate capsules) was studied. In vitro cell studies proved high cell viability of all inks. Due to the presence of nBG particles, more precise printed grids and pore sizes were achieved. Moreover, a decrease of the release of the model drug icariin in the presence of nBG particles was determined. The formation of a HAp layer on the surface of nBG-alginate capsules was assessed by FTIR, XRD and SEM. Overall, the addition of nBG particles into alginate hydrogels led to the improvement of the relevant properties investigated. Therefore, nBG-alginate systems should gain more attention for 3 D bioprinting and drug delivery approaches.

Abstract

Sodium alginate is a natural biocompatible polymer obtained from brown algae which has found numerous biomedical applications. Inorganic fillers, such as nanosized bioactive glass (nBG) particles, are well known for their outstanding properties in terms of being osteoconductive and osteoinductive and therefore finding application in bone tissue engineering. In this study, the impact of nBG particles on alginate hydrogels was investigated for applications of the composite hydrogel in biofabrication and drug delivery. The influence of nBG particles on properties such as printability, drug release ability and bioactivity (capability to form a hydroxyapatite (HAp) layer on the surface of nBG-alginate capsules) was studied. In vitro cell studies proved high cell viability of all inks. Due to the presence of nBG particles, more precise printed grids and pore sizes were achieved. Moreover, a decrease of the release of the model drug icariin in the presence of nBG particles was determined. The formation of a HAp layer on the surface of nBG-alginate capsules was assessed by FTIR, XRD and SEM. Overall, the addition of nBG particles into alginate hydrogels led to the improvement of the relevant properties investigated. Therefore, nBG-alginate systems should gain more attention for 3 D bioprinting and drug delivery approaches.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Conservative and Preventive Dentistry
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:General Health Professions
Language:English
Date:31 December 2022
Deposited On:01 Dec 2022 13:23
Last Modified:25 Mar 2024 04:40
Publisher:Taylor & Francis
ISSN:2688-9277
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/26889277.2022.2039078
Project Information:
  • : FunderDeutsche Forschungsgemeinschaft’
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)