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Effect of altered human exposome on the skin and mucosal epithelial barrier integrity


Pat, Yagiz; Ogulur, Ismail; Yazici, Duygu; Mitamura, Yasutaka; Cevhertas, Lacin; Küçükkase, Ozan C; Mesisser, Sanne S; Akdis, Mübeccel; Nadeau, Kari; Akdis, Cezmi A (2023). Effect of altered human exposome on the skin and mucosal epithelial barrier integrity. Tissue Barriers, 11(4):2133877.

Abstract

Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances and pollutants because of uncontrolled growth, modernization, and industrialization. More than 350,000 new chemicals have been introduced to our lives, mostly without any reasonable control of their health effects and toxicity. A plethora of studies show exposure to these harmful substances during this period with their implications on the skin and mucosal epithelial barrier and increasing prevalence of allergic and autoimmune diseases in the context of the "epithelial barrier hypothesis". Exposure to these substances causes an epithelial injury with peri-epithelial inflammation, microbial dysbiosis and bacterial translocation to sub-epithelial areas, and immune response to dysbiotic bacteria. Here, we provide scientific evidence on the altered human exposome and its impact on epithelial barriers.

Abstract

Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances and pollutants because of uncontrolled growth, modernization, and industrialization. More than 350,000 new chemicals have been introduced to our lives, mostly without any reasonable control of their health effects and toxicity. A plethora of studies show exposure to these harmful substances during this period with their implications on the skin and mucosal epithelial barrier and increasing prevalence of allergic and autoimmune diseases in the context of the "epithelial barrier hypothesis". Exposure to these substances causes an epithelial injury with peri-epithelial inflammation, microbial dysbiosis and bacterial translocation to sub-epithelial areas, and immune response to dysbiotic bacteria. Here, we provide scientific evidence on the altered human exposome and its impact on epithelial barriers.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Biochemistry
Health Sciences > Histology
Life Sciences > Cell Biology
Uncontrolled Keywords:Cell Biology, Histology, Biochemistry, Detergents; epithelial barrier; exposome; microplastics; nanoparticles; ozone; particulate matter
Language:English
Date:2 October 2023
Deposited On:12 Dec 2022 09:38
Last Modified:28 Jun 2024 01:36
Publisher:Taylor & Francis
ISSN:2168-8362
OA Status:Closed
Publisher DOI:https://doi.org/10.1080/21688370.2022.2133877
PubMed ID:36262078
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