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Longitudinal functional connectivity patterns of the default mode network in healthy older adults


Malagurski, Brigitta; Deschwanden, Pascal Frédéric; Jäncke, Lutz; Mérillat, Susan (2022). Longitudinal functional connectivity patterns of the default mode network in healthy older adults. NeuroImage, 259:119414.

Abstract

Cross-sectional studies have consistently identified age-associated alterations in default mode network (DMN) functional connectivity (FC). Yet, research on longitudinal trajectories of FC changes of the DMN in healthy aging is less conclusive. For the present study, we used a resting state functional MRI dataset drawn from the Longitudinal Healthy Aging Brain Database Project (LHAB) collected in 5 occasions over a course of 7 years (baseline N = 232, age range: 64-87 y, mean age = 70.85 y). FC strength changes within the DMN and its regions were investigated using a network-based statistical method suitable for the analysis of longitudinal data. The average DMN FC strength remained stable, however, various DMN components showed differential age- and time-related effects. Our results revealed a complex pattern of longitudinal change seen as decreases and increases of FC strength encompassing the majority of DMN regions, while age-related effects were negative and present in select brain areas. These findings testify to the growing importance of longitudinal studies using more sophisticated fine-grained tools needed to highlight the complexity of the functional reorganization of DMN with healthy aging.

Abstract

Cross-sectional studies have consistently identified age-associated alterations in default mode network (DMN) functional connectivity (FC). Yet, research on longitudinal trajectories of FC changes of the DMN in healthy aging is less conclusive. For the present study, we used a resting state functional MRI dataset drawn from the Longitudinal Healthy Aging Brain Database Project (LHAB) collected in 5 occasions over a course of 7 years (baseline N = 232, age range: 64-87 y, mean age = 70.85 y). FC strength changes within the DMN and its regions were investigated using a network-based statistical method suitable for the analysis of longitudinal data. The average DMN FC strength remained stable, however, various DMN components showed differential age- and time-related effects. Our results revealed a complex pattern of longitudinal change seen as decreases and increases of FC strength encompassing the majority of DMN regions, while age-related effects were negative and present in select brain areas. These findings testify to the growing importance of longitudinal studies using more sophisticated fine-grained tools needed to highlight the complexity of the functional reorganization of DMN with healthy aging.

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Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
08 Research Priority Programs > Dynamics of Healthy Aging
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Life Sciences > Neurology
Life Sciences > Cognitive Neuroscience
Language:English
Date:1 October 2022
Deposited On:12 Dec 2022 10:03
Last Modified:28 Apr 2024 01:40
Publisher:Elsevier
ISSN:1053-8119
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.neuroimage.2022.119414
PubMed ID:35760292
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)