Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Metal ion interactions with nucleic acids

Fazliji, Besim; Ferreira Rodrigues, Carla; Wang, Haibo; Sigel, Roland K O (2022). Metal ion interactions with nucleic acids. In: Black, David. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering / 2022. Waltham, MA: Elsevier, online.

Abstract

This chapter focuses on the interaction of metal ions mainly with RNA. It is an update of the previous Chapter 3.21 in the 2nd Edition of Comprehensive Inorganic Chemistry II (2013) but focusing solely on RNA. Metal ions are key to folding, structure, and function of any nucleic acid. These interactions are generally of a weak and highly dynamic nature as they concern mostly K+ and Mg2+ in living organisms. Aside from the large excess of loosely bound ions for charge compensation, a network of inner-sphere and outer-sphere interactions holds more specifically bound ions in place. Hence, metal ion binding to larger RNAs is rather complicated and has many facets. After a few general considerations on the basic properties of metal ions and the potential coordination sites on the RNA, the thermodynamics of metal ion binding to RNA and known metal ion binding motifs in RNA are described. This is followed by today's knowledge on the role of metal ions in folding, dynamics, sensing, and/or catalysis of riboswitches and ribozymes, respectively, is summarized.

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > General Engineering
Language:English
Date:2022
Deposited On:06 Jan 2023 14:31
Last Modified:22 Sep 2024 03:32
Publisher:Elsevier
ISBN:978-0-12-409547-2
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/b978-0-12-823144-9.00176-x
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications