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Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

Achimas-Cadariu, Patriciu; Kubelac, Paul; Irimie, Alexandru; Berindan-Neagoe, Ioana; Rühli, Frank (2022). Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present. Journal of Ovarian Research, 15:67.

Abstract

Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long history; however, recent cost-effective large-scale molecular profiling has started to provide novel insights coupled with the development of mathematical algorithms. In the current review, we have systematically searched for articles that focused on the clonal evolution of ovarian cancer to offer the whole landscape of research that has been done and highlight future research avenues given its characteristic features and connections to evolutionary biology.

Keywords: Clonal evolution; Ovarian cancer; Spatial heterogeneity; Survival; Temporal heterogeneity

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Evolutionary Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Health Sciences > Obstetrics and Gynecology
Uncontrolled Keywords:Obstetrics and Gynecology, Oncology
Language:English
Date:1 December 2022
Deposited On:09 Jan 2023 10:29
Last Modified:25 Feb 2025 02:40
Publisher:BioMed Central
ISSN:1757-2215
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/s13048-022-01004-1
PubMed ID:35659345
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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