Domestication is a process of protecting a particular set of individuals from some influences of their natural environment and managing their reproduction to suit particular needs of a domesticator. Biological characteristics of modern humans are a result of the process of auto-domestication that is continuing. Thus, they include disadvantages occurring in domesticated species: poor ability to cope with the external environment, reduced central nervous system plagued by mental abnormalities, gastrointestinal and metabolic deficiencies including reduced dentition, and musculoskeletal limitations. Since the process of autodomestication is continuing, these disadvantages will increase in future generations. At this stage of our bio-cultural evolution, we are being confronted by a pandemic of mental disorders which we are ill-equipped to address. This paper briefly discusses reasons why modern humans are more susceptible to mental disorders due to auto-domestication.