Chemical products are present in most households and can endanger the health of humans, particularly toddlers and pre-school children. With a focus on accident prevention, this article investigates parents and other caretakers’ beliefs and perspectives on risks and responsibilities. A mixed method approach was applied, combining in-depth qualitative interviews (pre-study, N = 10) and a quantitative survey (main study, N = 688) with Swiss caretakers of pre-school children. The questionnaire of the main study was developed based on the findings from the pre-study, and measured beliefs, perceptions of product, environmental risks, and responsibilities. The main findings suggest some prevalent misconceptions among parents regarding the risks of products perceived to be natural and the safety of child-protective caps. Furthermore, relationships were uncovered between psychological factors, such as perceived responsibility, trust and risk perception, and caretakers’ beliefs about household chemicals and their role in accident prevention. These beliefs highlight the need for preventive efforts focused on caretakers exhibiting pragmatic/trusting beliefs, compared to caretakers exhibiting protective or educational beliefs.