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In Vitro Validation of a New Tissue Oximeter Using Visible Light


Nasseri, Nassim; Kleiser, Stefan; Wolf, Ursula; Wolf, Martin (2022). In Vitro Validation of a New Tissue Oximeter Using Visible Light. In: Scholkmann, Felix; et al. Oxygen Transport to Tissue XLIII. Cham: Springer, 217-221.

Abstract

There is a clinical need to measure local tissue oxygen saturation (StO2), oxy-, deoxy- and total haemoglobin concentration ([O2Hb], [HHb], [tHb]) in human tissue. The aim was to validate an oximeter called OxyVLS applying visible light spectroscopy (VLS) to determine these parameters without needing to assume a reduced scattering coefficient (μ's). This problem is solved by appropriate calibrations. Compared to near-infrared spectroscopy (NIRS), OxyVLS determines the oxygenation in a much smaller more superficial volume of tissue, which is useful in many clinical cases. OxyVLS was validated in liquid phantoms with known StO2, [tHb], and μ's and compared to frequency domain NIRS as a reliable reference. OxyVLS showed a high accuracy for all the mentioned parameters and was even able to measure μ's. Thus, OxyVLS was successfully tested in vitro.

Keywords: Liquid phantom; Local tissue oxygen saturation; StO2; Visible light spectroscopy

Abstract

There is a clinical need to measure local tissue oxygen saturation (StO2), oxy-, deoxy- and total haemoglobin concentration ([O2Hb], [HHb], [tHb]) in human tissue. The aim was to validate an oximeter called OxyVLS applying visible light spectroscopy (VLS) to determine these parameters without needing to assume a reduced scattering coefficient (μ's). This problem is solved by appropriate calibrations. Compared to near-infrared spectroscopy (NIRS), OxyVLS determines the oxygenation in a much smaller more superficial volume of tissue, which is useful in many clinical cases. OxyVLS was validated in liquid phantoms with known StO2, [tHb], and μ's and compared to frequency domain NIRS as a reliable reference. OxyVLS showed a high accuracy for all the mentioned parameters and was even able to measure μ's. Thus, OxyVLS was successfully tested in vitro.

Keywords: Liquid phantom; Local tissue oxygen saturation; StO2; Visible light spectroscopy

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Language:English
Date:2022
Deposited On:16 Jan 2023 10:21
Last Modified:17 Jan 2023 21:01
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
ISSN:0065-2598
ISBN:978-3-031-14192-8
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-3-031-14190-4_36
PubMed ID:36527640