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Test-retest reliability of lung diffusing capacity for nitric oxide during light to moderate intensity cycling exercise

Alves, Manuel Monteiro; Dressel, Holger; Radtke, Thomas (2022). Test-retest reliability of lung diffusing capacity for nitric oxide during light to moderate intensity cycling exercise. Respiratory Physiology & Neurobiology, 304:103940.

Abstract

This study examined test-retest reliability of single-breath lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) during exercise. Sixteen healthy subjects (age 20-67 years) performed DLNO-DLCO tests during light and moderate intensity cycling exercise at 50% and 80% of individual anaerobic threshold (IAT). Primary endpoint was DLNO at 80% IAT. Precision of DLNO, DLCO, and alveolar volume was quantified by within-subject standard deviation (SDws, measurement error) and intraclass correlation coefficients (ICC). Reproducibility was determined by SDws* 2.77. Overall, reliability was excellent for all outcomes. SDws and reproducibility for DLNO at 80% IAT were 4.6 and 12.7 mL.min-1.mmHg-1, and the ICC was 0.99 (95% confidence interval 0.98-0.99). Median breathlessness at 80% IAT was 4 (interquartile range 3-6) on a 0-10 scale. Our data suggest excellent reliability of single-breath DLNO during moderate intensity exercise, but perceived levels of breathlessness may limit its usefulness, especially at exercise intensities beyond IAT.

Keywords: Diffusing capacity for nitric oxide; Exercise; Reliability; Reproducibility; Single breath

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Life Sciences > Physiology
Health Sciences > Pulmonary and Respiratory Medicine
Language:English
Date:October 2022
Deposited On:20 Jan 2023 10:56
Last Modified:29 Oct 2024 02:35
Publisher:Elsevier
ISSN:1569-9048
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.resp.2022.103940
PubMed ID:35777723
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