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The micronucleus test


Schmid, Werner (1975). The micronucleus test. Mutation Research - Section on Environmental Mutagenesis and Related Subjects, 31(1):9-15.

Abstract

The micronucleus test (m.t.) in vivo is a method devised primarily for screening chemicals for chromosome-breaking effects. The test substances are normally applied sub-acutely to small mammals, and the effect is read in direct smears from bone marrow.
This testing procedure, developed by SCHMID and coworkers1~3~5~6 has a number of important advantages over the analysis of bone-marrow metaphase chromosomes. In technique of preparation as well as the reading of the slides, it is simpler and faster than chromosome analysis in the same material, but not at the expense of accuracy.

Abstract

The micronucleus test (m.t.) in vivo is a method devised primarily for screening chemicals for chromosome-breaking effects. The test substances are normally applied sub-acutely to small mammals, and the effect is read in direct smears from bone marrow.
This testing procedure, developed by SCHMID and coworkers1~3~5~6 has a number of important advantages over the analysis of bone-marrow metaphase chromosomes. In technique of preparation as well as the reading of the slides, it is simpler and faster than chromosome analysis in the same material, but not at the expense of accuracy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Toxicology
Life Sciences > Genetics
Uncontrolled Keywords:Genetics, Toxicology, micronucleus test
Language:English
Date:1 February 1975
Deposited On:26 Jan 2023 06:45
Last Modified:28 Apr 2024 01:46
Publisher:Elsevier
ISSN:0165-1161
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/0165-1161(75)90058-8