Header

UZH-Logo

Maintenance Infos

The Micronucleus Test for Cytogenetic Analysis


Schmid, Werner (1976). The Micronucleus Test for Cytogenetic Analysis. In: Hollaender, A. Chemical Mutagens. Chapter 36: Springer, 31-53.

Abstract

Micronuclei originate from chromatin which for different reasons has been lagging in anaphase (Fig. la-d). In the course of telophase this material is included into one or the other daughter cell where it either can fuse with the main nucleus or form one or several secondary nuclei. These are, as a rule, considerably smaller than the principal nucleus and are therefore called micronuclei. Lagging has two main causes: chromosome breakage and malfunction of the spindle apparatus. In the first case the lagging elements are acentric chromosome fragments and di- or multicentrics connected by bridges, and in the second case they consist of entire chromosomes.

Abstract

Micronuclei originate from chromatin which for different reasons has been lagging in anaphase (Fig. la-d). In the course of telophase this material is included into one or the other daughter cell where it either can fuse with the main nucleus or form one or several secondary nuclei. These are, as a rule, considerably smaller than the principal nucleus and are therefore called micronuclei. Lagging has two main causes: chromosome breakage and malfunction of the spindle apparatus. In the first case the lagging elements are acentric chromosome fragments and di- or multicentrics connected by bridges, and in the second case they consist of entire chromosomes.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

0 downloads since deposited on 26 Jan 2023
0 downloads since 12 months

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Cytogenetic Analysis, Genetics
Language:English
Date:1 January 1976
Deposited On:26 Jan 2023 06:53
Last Modified:26 Jan 2023 06:53
Publisher:Springer
ISBN:9781468408942
Additional Information:Only the two first pages are available for free. The full chapter can be downloaded against a fee.
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-1-4684-0892-8_2