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Trenimon-induced chromosomal damage in bone-marrow cells of six mammalian species, evaluated by the micronucleus test


Matter, B; Schmid, Werner (1971). Trenimon-induced chromosomal damage in bone-marrow cells of six mammalian species, evaluated by the micronucleus test. Mutation research, 12(4):417-425.

Abstract

2,3,5-Tris-ethyleneiminobenzoquinone (1,4), a strong alkylating mutagen, was used in vivo to induce chromosomal damage in bone-marrow cells of the following species: Chinese and Syrian hamster, mouse, rat and guinea pig. Four different single doses between 0.031 and 0.25 mg/kg were tested. In addition, some pilot studies were performed on Rhesus monkeys. The preparations were scored for three types of aberration: micronuclei in erythrocytes (Jolly bodies), micronuclei in white cells and nuclei in lysis. A dose-dependent increase in the incidence of the three types of aberration was found in all six species with no major interspecific differences in the total percentages of nuclear anomalies. The results are in good correlation with those obtained with the cytogenetic method in Chinese hamster bone marrow. The micronucleus test appears to be a useful method offering the advantages of technical simplicity and applicability to a wide range of test mammals, irrespective of a cytologically favorable karyotype.

Abstract

2,3,5-Tris-ethyleneiminobenzoquinone (1,4), a strong alkylating mutagen, was used in vivo to induce chromosomal damage in bone-marrow cells of the following species: Chinese and Syrian hamster, mouse, rat and guinea pig. Four different single doses between 0.031 and 0.25 mg/kg were tested. In addition, some pilot studies were performed on Rhesus monkeys. The preparations were scored for three types of aberration: micronuclei in erythrocytes (Jolly bodies), micronuclei in white cells and nuclei in lysis. A dose-dependent increase in the incidence of the three types of aberration was found in all six species with no major interspecific differences in the total percentages of nuclear anomalies. The results are in good correlation with those obtained with the cytogenetic method in Chinese hamster bone marrow. The micronucleus test appears to be a useful method offering the advantages of technical simplicity and applicability to a wide range of test mammals, irrespective of a cytologically favorable karyotype.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Biology
Life Sciences > Genetics
Physical Sciences > Health, Toxicology and Mutagenesis
Uncontrolled Keywords:Health, Toxicology and Mutagenesis, Genetics, Molecular Biology
Language:English
Date:1 August 1971
Deposited On:26 Jan 2023 06:38
Last Modified:28 Apr 2024 01:46
Publisher:Elsevier
ISSN:0027-5107
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/0027-5107(71)90092-3
PubMed ID:4999599
Other Identification Number:Corpus ID: 8748595