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X-linked dominant hypophosphatemia is closely linked to DNA markers DXS41 and DXS43 at Xp22


Mächler, Marco; Frey, D; Gal, A; Orth, U; Wienker, T F; Fanconi, A; Schmid, Werner (1986). X-linked dominant hypophosphatemia is closely linked to DNA markers DXS41 and DXS43 at Xp22. Human Genetics, 73(3):271-275.

Abstract

Two families with X-linked dominant hypophosphatemia (McKusick No. *30780) were investigated for linkage of the disease locus with several marker genes defined by cloned, single-copy DNA sequences derived from defined regions of the X chromosome. Close linkage was found with DNA markers DXS41 (p99-6) and DXS43 (pD2) at Xp22, suggesting a location of the HPDR gene on the distal short arm of the X chromosome.

Abstract

Two families with X-linked dominant hypophosphatemia (McKusick No. *30780) were investigated for linkage of the disease locus with several marker genes defined by cloned, single-copy DNA sequences derived from defined regions of the X chromosome. Close linkage was found with DNA markers DXS41 (p99-6) and DXS43 (pD2) at Xp22, suggesting a location of the HPDR gene on the distal short arm of the X chromosome.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Genetics
Health Sciences > Genetics (clinical)
Uncontrolled Keywords:Genetics (clinical), Genetics, Internal Medicine, Metabolic Disease, Marker Gene, Disease Locus, Close Linkage
Language:English
Date:1 July 1986
Deposited On:27 Jan 2023 12:11
Last Modified:28 Apr 2024 01:47
Publisher:Springer
ISSN:0340-6717
Additional Information:Prof. Dr. med. Werner Schmid (Director of the institute till 1996)
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/bf00401243
PubMed ID:3015771
Other Identification Number:Corpus ID: 26634255