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Comparison of alfaxalone and propofol on haematological and serum biochemical variables in cats undergoing radiotherapy with sevoflurane maintenance


Körner, Maximilian; Rohrer Bley, Carla; Bektas, Rima N; Riond, Barbara; Wolf, Friederike; Meier, Valeria Sabina (2023). Comparison of alfaxalone and propofol on haematological and serum biochemical variables in cats undergoing radiotherapy with sevoflurane maintenance. Veterinary Anaesthesia and Analgesia, 50(2):146-156.

Abstract

Objective: To evaluate effects of repeated alfaxalone or propofol administration on haematological and serum biochemical variables in cats undergoing radiotherapy.
Study design: Prospective, block-randomized, clinical trial.
Animals: A group of 39 client-owned cats.
Methods: After butorphanol (0.2 mg kg–1) and midazolam (0.1 mg kg–1) sedation, cats were randomly assigned to be administered either alfaxalone or propofol for induction of anaesthesia and sevoflurane maintenance. Cats were anaesthetized daily with the same induction agent for 10–12 days. Complete blood counts, reticulocytes, Heinz body score and serum biochemistry were performed before the first treatment (T1), at T6, T10 and 3 weeks after the final treatment (T21). Cumulative induction agent dose for each cat at each time point was evaluated for an effect on Heinz body score. Data are shown as mean ± standard deviation; p < 0.05.
Results: At baseline there were no significant differences in signalment or blood variables between groups. A significant decrease in haematocrit of 2.3% ± 0.77 (p = 0.02) between T1-T6 and T1-T10 [mean 4.1% (±0.78, p < 0.0001)] was detected, with a significant increase in haematocrit of 2.1% ± 0.80 (p = 0.046) between T6-T21 and 4.0% ± 0.8 (p < 0.001) between T10-T21. Heinz body score significantly increased by 1.86 ± 0.616 (p = 0.013) between T1-T10. In the propofol group, reticulocytes increased significantly between T1-T6 [mean 23,090 μL–1 ± 7670 (p = 0.02)] and T1-T10 [mean 27,440 μL–1 ± 7990 (p = 0.007)]. Mean cumulative dose at T10 was 19.65 mg kg–1 ± 5.3 and 43.4 mg kg–1 ± 14.4 for alfaxalone and propofol, respectively, with no significant effect on Heinz body formation at any time point.
Conclusions and Clinical relevance: Haematocrit decreased in both groups with recovery after 3 weeks. Repeated alfaxalone and propofol administration was not associated with marked haematological or serum biochemistry changes.

Abstract

Objective: To evaluate effects of repeated alfaxalone or propofol administration on haematological and serum biochemical variables in cats undergoing radiotherapy.
Study design: Prospective, block-randomized, clinical trial.
Animals: A group of 39 client-owned cats.
Methods: After butorphanol (0.2 mg kg–1) and midazolam (0.1 mg kg–1) sedation, cats were randomly assigned to be administered either alfaxalone or propofol for induction of anaesthesia and sevoflurane maintenance. Cats were anaesthetized daily with the same induction agent for 10–12 days. Complete blood counts, reticulocytes, Heinz body score and serum biochemistry were performed before the first treatment (T1), at T6, T10 and 3 weeks after the final treatment (T21). Cumulative induction agent dose for each cat at each time point was evaluated for an effect on Heinz body score. Data are shown as mean ± standard deviation; p < 0.05.
Results: At baseline there were no significant differences in signalment or blood variables between groups. A significant decrease in haematocrit of 2.3% ± 0.77 (p = 0.02) between T1-T6 and T1-T10 [mean 4.1% (±0.78, p < 0.0001)] was detected, with a significant increase in haematocrit of 2.1% ± 0.80 (p = 0.046) between T6-T21 and 4.0% ± 0.8 (p < 0.001) between T10-T21. Heinz body score significantly increased by 1.86 ± 0.616 (p = 0.013) between T1-T10. In the propofol group, reticulocytes increased significantly between T1-T6 [mean 23,090 μL–1 ± 7670 (p = 0.02)] and T1-T10 [mean 27,440 μL–1 ± 7990 (p = 0.007)]. Mean cumulative dose at T10 was 19.65 mg kg–1 ± 5.3 and 43.4 mg kg–1 ± 14.4 for alfaxalone and propofol, respectively, with no significant effect on Heinz body formation at any time point.
Conclusions and Clinical relevance: Haematocrit decreased in both groups with recovery after 3 weeks. Repeated alfaxalone and propofol administration was not associated with marked haematological or serum biochemistry changes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 March 2023
Deposited On:27 Jan 2023 10:09
Last Modified:30 Jan 2024 02:41
Publisher:Elsevier
ISSN:1467-2987
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.vaa.2022.11.010
PubMed ID:36759290
  • Content: Accepted Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)