Header

UZH-Logo

Maintenance Infos

Impact of Pro-Argin on the Oral Health-Related Quality of Life: A 24-Week Randomized, Parallel-Group, Multicenter Study


Michaelis, Mary; Hirsiger, Constanze; Roux, Dominique; Schmidlin, Patrick Roger; Attin, Thomas; Doméjean, Sophie; Hirsch, Christian; Heumann, Christian; Schaller, Hans-Günter; Gernhardt, Christian Ralf (2022). Impact of Pro-Argin on the Oral Health-Related Quality of Life: A 24-Week Randomized, Parallel-Group, Multicenter Study. Applied Sciences, 12(9):4431.

Abstract

To assess the efficacy of Pro-Argin with respect to the oral health-related quality of life (OHRQoL) and cervical dentine hypersensitivity (CDH) in subjects with CDH for 24 weeks compared to a control group. Three study centers (one each in France, Germany, and Switzerland) included 273 subjects for 24 weeks. Patients with CDH involving at least two non-molar teeth and those with Schiff scores (cold air sensitivity scale) of 2 or 3 were included. The primary study parameter was a change in the OHRQoL from baseline to 24 weeks, as assessed by the Oral Health Impact Profile (OHIP)-49 questionnaire within and between the randomized groups. Patients were randomly assigned to the test group (TG) or the control group (CG). Prophylaxis paste and toothpaste in the TG contained 8% arginine and calcium carbonate. The toothpaste in the CG contained sodium monofluorophosphate. The level of significance was set at 5% (p = 0.05). The OHIP-49 at 24 weeks was analyzed using the analysis of covariance (ANCOVA). The mean OHIP-49 score after 24 weeks (adjusted for baseline) was significantly lower in the TG than in the CG (p = 0.005, ANCOVA). The OHIP-49 pain-related items adjusted for the baseline values also showed significant differences between the groups (p = 0.025, ANCOVA). The treatment over a period of 24 weeks using products based on the Pro-Argin technology showed a significant improvement in the OHRQoL compared to the placebo application.

Abstract

To assess the efficacy of Pro-Argin with respect to the oral health-related quality of life (OHRQoL) and cervical dentine hypersensitivity (CDH) in subjects with CDH for 24 weeks compared to a control group. Three study centers (one each in France, Germany, and Switzerland) included 273 subjects for 24 weeks. Patients with CDH involving at least two non-molar teeth and those with Schiff scores (cold air sensitivity scale) of 2 or 3 were included. The primary study parameter was a change in the OHRQoL from baseline to 24 weeks, as assessed by the Oral Health Impact Profile (OHIP)-49 questionnaire within and between the randomized groups. Patients were randomly assigned to the test group (TG) or the control group (CG). Prophylaxis paste and toothpaste in the TG contained 8% arginine and calcium carbonate. The toothpaste in the CG contained sodium monofluorophosphate. The level of significance was set at 5% (p = 0.05). The OHIP-49 at 24 weeks was analyzed using the analysis of covariance (ANCOVA). The mean OHIP-49 score after 24 weeks (adjusted for baseline) was significantly lower in the TG than in the CG (p = 0.005, ANCOVA). The OHIP-49 pain-related items adjusted for the baseline values also showed significant differences between the groups (p = 0.025, ANCOVA). The treatment over a period of 24 weeks using products based on the Pro-Argin technology showed a significant improvement in the OHRQoL compared to the placebo application.

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Downloads

14 downloads since deposited on 02 Feb 2023
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Conservative and Preventive Dentistry
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Fluid Flow and Transfer Processes, Computer Science Applications, Process Chemistry and Technology, General Engineering, Instrumentation, General Materials Science
Language:English
Date:27 April 2022
Deposited On:02 Feb 2023 07:05
Last Modified:28 Apr 2024 01:47
Publisher:MDPI Publishing
ISSN:2076-3417
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.3390/app12094431
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)