Header

UZH-Logo

Maintenance Infos

Natural killer cell responses to human oncogenic γ-herpesvirus infections


Münz, Christian (2022). Natural killer cell responses to human oncogenic γ-herpesvirus infections. Seminars in Immunology, 60:101652.

Abstract

The two γ-herpesviruses Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are each associated with more than 1% of all tumors in humans. While EBV establishes persistent infection in nearly all adult individuals, KSHV benefits from this widespread EBV prevalence for its own persistence. Interestingly, EBV infection expands early differentiated NKG2A+KIR- NK cells that protect against lytic EBV infection, while KSHV co-infection drives accumulation of poorly functional CD56-CD16+ NK cells. Thus persistent γ-herpesvirus infections are sculptors of human NK cell repertoires and the respectively stimulated NK cell subsets should be considered for immunotherapies of EBV and KSHV associated malignancies.

Keywords: Cytotoxicity; Epstein Barr virus (EBV); Humanized mice; Kaposi sarcoma associated herpesvirus; NKG2A; NKG2D

Abstract

The two γ-herpesviruses Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are each associated with more than 1% of all tumors in humans. While EBV establishes persistent infection in nearly all adult individuals, KSHV benefits from this widespread EBV prevalence for its own persistence. Interestingly, EBV infection expands early differentiated NKG2A+KIR- NK cells that protect against lytic EBV infection, while KSHV co-infection drives accumulation of poorly functional CD56-CD16+ NK cells. Thus persistent γ-herpesvirus infections are sculptors of human NK cell repertoires and the respectively stimulated NK cell subsets should be considered for immunotherapies of EBV and KSHV associated malignancies.

Keywords: Cytotoxicity; Epstein Barr virus (EBV); Humanized mice; Kaposi sarcoma associated herpesvirus; NKG2A; NKG2D

Statistics

Citations

Dimensions.ai Metrics
6 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

28 downloads since deposited on 30 Jan 2023
24 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology, Immunology and Allergy
Language:English
Date:1 March 2022
Deposited On:30 Jan 2023 10:54
Last Modified:29 May 2024 01:46
Publisher:Elsevier
ISSN:1044-5323
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.smim.2022.101652
PubMed ID:36162228
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)