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The Microbiome Forensics Database UZH

Arora, Natasha; Matias Rodrigues, Joao Frederico; Swayambhu, Meghna; Witlox, Pim (2022). The Microbiome Forensics Database UZH. Forensic Science International: Genetics Supplement Series, 8:181-184.

Abstract

Microbial communities in biological stains can provide valuable information to assist forensic scientists identify the body fluid/tissue present in these. As these microbial communities are characteristic of body habitats, DNA sequencing of microbes can be used to predict bodily origin. Promising predictive results have been obtained with supervised machine learning algorithms trained on bacterial abundance data from human body sites. Importantly, prediction accuracy is dependent on the training dataset, yet compiling a large and comprehensive training reference is a non-trivial issue requiring substantial efforts. Here we present a new online database and associated data-mining platform which is, to our knowledge, the first one customised for forensic scientists investigating body fluids/tissues. Our database features samples originating from ten human body sites, with selection options through an online platform. Users can download bacterial abundance as well as taxonomic data, which can then be used to train predictive models and test their accuracy. Future stages of the development of the platform will include curation of the samples to decrease potential errors in sample labelling, as well as access to an online tool to conduct exploratory analyses.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Scopus Subject Areas:Health Sciences > Pathology and Forensic Medicine
Life Sciences > Genetics
Uncontrolled Keywords:Genetics, Pathology and Forensic Medicine
Language:English
Date:1 December 2022
Deposited On:15 Feb 2023 15:02
Last Modified:23 Mar 2025 04:34
Publisher:Elsevier
ISSN:1875-175X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.fsigss.2022.10.028

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