Header

UZH-Logo

Maintenance Infos

Increased parental ages and uniparental disomy 15: a paternal age effect?


Robinson, Wendy P; Lorda-Sanchez, Isabel; Malcolm, S; Langlois, S; Schuffenhauer, S; Knoblauch, Hubert; Horsthemke, Bernhard; Schinzel, Albert (1993). Increased parental ages and uniparental disomy 15: a paternal age effect? European Journal of Human Genetics, 1(4):280-286.

Abstract

Parental ages associated with both maternal and paternal uniparental disomy (UPD) of chromosome 15 are highly elevated in comparison to Zurich population-based controls, with mean maternal and paternal ages of 35.6 and 38.1, respectively for UPD patients (diagnosed in Zurich) and 28.0 and 31.0, in controls. The parental ages are also significantly higher than observed for trisomies of other chromosomes diagnosed in Zurich. The higher age of UPD cases may be due to the fact that two errors, both a gain and a loss of a chromosome 15, are necessary. We suggest that gamete complementation, zygote formation from two gametes one of which is nullisomic and the other disomic for the same chromosome, may be a major mechanism of UPD formation, as well as secondary loss of a chromosome in a trisomic conception, and that there is an association between increased paternal age and nondisjunction.

Abstract

Parental ages associated with both maternal and paternal uniparental disomy (UPD) of chromosome 15 are highly elevated in comparison to Zurich population-based controls, with mean maternal and paternal ages of 35.6 and 38.1, respectively for UPD patients (diagnosed in Zurich) and 28.0 and 31.0, in controls. The parental ages are also significantly higher than observed for trisomies of other chromosomes diagnosed in Zurich. The higher age of UPD cases may be due to the fact that two errors, both a gain and a loss of a chromosome 15, are necessary. We suggest that gamete complementation, zygote formation from two gametes one of which is nullisomic and the other disomic for the same chromosome, may be a major mechanism of UPD formation, as well as secondary loss of a chromosome in a trisomic conception, and that there is an association between increased paternal age and nondisjunction.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

0 downloads since deposited on 24 Apr 2023
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Genetics
Health Sciences > Genetics (clinical)
Uncontrolled Keywords:Genetics (medical, Genteics, Parental age, Nondisjunction, Uniparental disomy, Chromosome 15, Prader-Willi syndrome, Angelman syndrome
Language:English
Date:1993
Deposited On:24 Apr 2023 08:46
Last Modified:29 Mar 2024 04:34
Publisher:Nature Publishing Group
ISSN:1018-4813
OA Status:Closed
Publisher DOI:https://doi.org/10.1159/000472425
Official URL:https://www.nature.com/articles/000472425
PubMed ID:8081941