Genome-wide association study identifies five susceptibility loci for glioma

Shete, S; Hosking, F J; Robertson, L B; Dobbins, S E; Sanson, M; Malmer, B; Simon, M; Marie, Y; Boisselier, B; Delattre, J Y; Hoang-Xuan, K; El Hallani, S; Idbaih, A; Zelenika, D; Andersson, U; Henriksson, R; Bergenheim, A T; Feychting, M; Lönn, S; Ahlbom, A; Schramm, J; Linnebank, M; Hemminki, K; Kumar, R; Hepworth, S J; Price, A; Armstrong, G; Liu, Y; Gu, X; Yu, R; Lau, C; Schoemaker, M; Muir, K; Swerdlow, A; Lathrop, M; Bondy, M; Houlston, R S

doi:10.1038/ng.407

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Genome-wide association study identifies five susceptibility loci for glioma

Shete, S; Hosking, F J; Robertson, L B; Dobbins, S E; Sanson, M; Malmer, B; Simon, M; Marie, Y; Boisselier, B; Delattre, J Y; Hoang-Xuan, K; El Hallani, S; Idbaih, A; Zelenika, D; Andersson, U; Henriksson, R; Bergenheim, A T; Feychting, M; Lönn, S; Ahlbom, A; Schramm, J; Linnebank, M; Hemminki, K; Kumar, R; Hepworth, S J; Price, A; Armstrong, G; Liu, Y; Gu, X; Yu, R; Lau, C; Schoemaker, M; Muir, K; Swerdlow, A; Lathrop, M; Bondy, M; Houlston, R S (2009). Genome-wide association study identifies five susceptibility loci for glioma. Nature Genetics, 41(8):899-904.

Abstract

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

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Item Type:	Journal Article, refereed, original work
Communities & Collections:	04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:	610 Medicine & health
Scopus Subject Areas:	Life Sciences > Genetics
Language:	English
Date:	August 2009
Deposited On:	02 Nov 2009 09:21
Last Modified:	27 Jun 2022 07:36
Publisher:	Nature Publishing Group
ISSN:	1061-4036
OA Status:	Green
Free access at:	PubMed ID. An embargo period may apply.
Publisher DOI:	https://doi.org/10.1038/ng.407
PubMed ID:	19578367