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A virtual audit system for intensity-modulated radiation therapy credentialing in Japan Clinical Oncology Group clinical trials: A pilot study

Nakamura, Mitsuhiro; Zhou, Dejun; Minemura, Toshiyuki; Kito, Satoshi; Okamoto, Hiroyuki; Tohyama, Naoki; Kurooka, Masahiko; Kumazaki, Yu; Ishikawa, Masayori; Clark, Catharine H; Miles, Elizabeth; Lehmann, Joerg; Andratschke, Nicolaus; Kry, Stephen; Ishikura, Satoshi; Mizowaki, Takashi; Nishio, Teiji (2023). A virtual audit system for intensity-modulated radiation therapy credentialing in Japan Clinical Oncology Group clinical trials: A pilot study. Journal of Applied Clinical Medical Physics, 24(6):e14040.

Abstract

PURPOSE

The Medical Physics Working Group of the Radiation Therapy Study Group at the Japan Clinical Oncology Group is currently developing a virtual audit system for intensity-modulated radiation therapy dosimetry credentialing. The target dosimeters include films and array detectors, such as ArcCHECK (Sun Nuclear Corporation, Melbourne, Florida, USA) and Delta4 (ScandiDos, Uppsala, Sweden). This pilot study investigated the feasibility of our virtual audit system using previously acquired data.

METHODS

We analyzed 46 films (32 and 14 in the axial and coronal planes, respectively) from 29 institutions. Global gamma analysis between measured and planned dose distributions used the following settings: 3%/3 mm criteria (the dose denominator was 2 Gy), 30% threshold dose, no scaling of the datasets, and 90% tolerance level. In addition, 21 datasets from nine institutions were obtained for array evaluation. Five institutions used ArcCHECK, while the others used Delta4. Global gamma analysis was performed with 3%/2 mm criteria (the dose denominator was the maximum calculated dose), 10% threshold dose, and 95% tolerance level. The film calibration and gamma analysis were conducted with in-house software developed using Python (version 3.9.2).

RESULTS

The means ± standard deviations of the gamma passing rates were 99.4 ± 1.5% (range, 92.8%-100%) and 99.2 ± 1.0% (range, 97.0%-100%) in the film and array evaluations, respectively.

CONCLUSION

This pilot study demonstrated the feasibility of virtual audits. The proposed virtual audit system will contribute to more efficient, cheaper, and more rapid trial credentialing than on-site and postal audits; however, the limitations should be considered when operating our virtual audit system.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Radiation
Physical Sciences > Instrumentation
Health Sciences > Radiology, Nuclear Medicine and Imaging
Language:English
Date:June 2023
Deposited On:20 Jul 2023 06:32
Last Modified:29 Dec 2024 02:38
Publisher:The American College of Medical Physics and American Institute of Physics
ISSN:1526-9914
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/acm2.14040
PubMed ID:37191875
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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