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Somatic pairings of the Y heterochromatin in human XYY and XYqi cells


Schmid, M; Poppen, A; Schmid, Werner; Engel, W (1981). Somatic pairings of the Y heterochromatin in human XYY and XYqi cells. Cytogenetics and cell genetics, 29(4):203-214.

Abstract

In human interphase nuclei containing Yq isochromosomes or two Y chromosomes, there are conspicuous somatic pairings between the brightly fluorescing Y-heterochromatin regions. These somatic pairings cannot be demonstrated in metaphases from conventional cell cultures because they are disrupted at the mitotic prophase. However, in lymphocytes cultivated in a medium containing distamycin A, the somatic pairing between Y-heterochromatin is preserved to metaphase. The present findings are compared with earlier observations of somatically paired heterochromatin. An explanation for the highly disparate frequency of somatic pairing between the Y-heterochromatin regions in Yq isochromosomes and YY chromosomes is proposed.

Abstract

In human interphase nuclei containing Yq isochromosomes or two Y chromosomes, there are conspicuous somatic pairings between the brightly fluorescing Y-heterochromatin regions. These somatic pairings cannot be demonstrated in metaphases from conventional cell cultures because they are disrupted at the mitotic prophase. However, in lymphocytes cultivated in a medium containing distamycin A, the somatic pairing between Y-heterochromatin is preserved to metaphase. The present findings are compared with earlier observations of somatically paired heterochromatin. An explanation for the highly disparate frequency of somatic pairing between the Y-heterochromatin regions in Yq isochromosomes and YY chromosomes is proposed.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Genetics
Life Sciences > Cell Biology
Uncontrolled Keywords:Genetics (clinical), Chromosome Aberrations / genetics, Chromosome Banding, Chromosome Disorders, Distamycins / pharmacology, Heterochromatin / ultrastructure, Humans, Male, Metaphase, Sex Chromosomes / ultrastructure, XYY Karyotype / genetics, Y Chromosome / drug effects, Y Chromosome / ultrastructure
Language:English
Date:1981
Deposited On:11 Aug 2023 06:49
Last Modified:29 Apr 2024 01:38
Publisher:Karger
ISSN:0301-0171
OA Status:Closed
Publisher DOI:https://doi.org/10.1159/000131571
PubMed ID:7238123