Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

The functional connectome of 3,4‐methyldioxymethamphetamine‐related declarative memory impairments

Coray, Rebecca C; Zimmermann, Josua; Haugg, Amelie; Baumgartner, Markus R; Steuer, Andrea Eva; Seifritz, Erich; Stock, Ann‐Kathrin; Beste, Christian; Cole, David M; Quednow, Boris B (2023). The functional connectome of 3,4‐methyldioxymethamphetamine‐related declarative memory impairments. Human Brain Mapping, 44(15):5079-5094.

Abstract

The chronic intake of 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) bears a strong risk for sustained declarative memory impairments. Although such memory deficits have been repeatedly reported, their neurofunctional origin remains elusive. Therefore, we here investigate the neuronal basis of altered declarative memory in recurrent MDMA users at the level of brain connectivity. We examined a group of 44 chronic MDMA users and 41 demographically matched controls. Declarative memory performance was assessed by the Rey Auditory Verbal Learning Test and a visual associative learning test. To uncover alterations in the whole brain connectome between groups, we employed a data‐driven multi‐voxel pattern analysis (MVPA) approach on participants' resting‐state functional magnetic resonance imaging data. Recent MDMA use was confirmed by hair analyses. MDMA users showed lower performance in delayed recall across tasks compared to well‐matched controls with moderate‐to‐strong effect sizes. MVPA revealed a large cluster located in the left postcentral gyrus of global connectivity differences between groups. Post hoc seed‐based connectivity analyses with this cluster unraveled hypoconnectivity to temporal areas belonging to the auditory network and hyperconnectivity to dorsal parietal regions belonging to the dorsal attention network in MDMA users. Seed‐based connectivity strength was associated with verbal memory performance in the whole sample as well as with MDMA intake patterns in the user group. Our findings suggest that functional underpinnings of MDMA‐related memory impairments encompass altered patterns of multimodal sensory integration within auditory processing regions to a functional heteromodal connector hub, the left postcentral gyrus. In addition, hyperconnectivity in regions of a cognitive control network might indicate compensation for degraded sensory processing.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Scopus Subject Areas:Health Sciences > Anatomy
Health Sciences > Radiological and Ultrasound Technology
Health Sciences > Radiology, Nuclear Medicine and Imaging
Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Uncontrolled Keywords:Neurology (clinical), Neurology, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Anatomy MDMA; MVPA; auditory network; cognitive control network; imaging; memory consolidation; serotonin; stimulants; verbal memory.
Language:English
Date:15 October 2023
Deposited On:15 Aug 2023 14:35
Last Modified:29 Dec 2024 02:39
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1065-9471
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/hbm.26438
PubMed ID:37530403
Project Information:
  • Funder: Novartis
  • Grant ID: 19C167
  • Project Title: 19C167/Novartis Foundation for Medical Biological Research
  • Funder: SNF
  • Grant ID: 320030L_179450
  • Project Title: 320030L_179450/Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Funder: DFG
  • Grant ID: BE4045/34-1
  • Project Title: BE4045/34-1/German Research Foundation (DFG)
Download PDF  'The functional connectome of 3,4‐methyldioxymethamphetamine‐related declarative memory impairments'.
Preview
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
3 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

13 downloads since deposited on 15 Aug 2023
10 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications