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Reptarenavirus S Segment RNA Levels Correlate with the Presence of Inclusion Bodies and the Number of L Segments in Snakes with Reptarenavirus Infection—Lessons Learned from a Large Breeding Colony

Thiele, Tanja; Baggio, Francesca; Prähauser, Barbara; Ruiz Subira, Andres; Michalopoulou, Eleni; Kipar, Anja; Hetzel, Udo; Hepojoki, Jussi (2023). Reptarenavirus S Segment RNA Levels Correlate with the Presence of Inclusion Bodies and the Number of L Segments in Snakes with Reptarenavirus Infection—Lessons Learned from a Large Breeding Colony. Microbiology Spectrum, 11(3):e0506522.

Abstract

Boid inclusion body disease (BIBD) is caused by reptarenavirus infection, and while reptarenavirus nucleoprotein is the main component of the inclusion bodies (IBs) characteristic of BIBD, not all reptarenavirus-infected snakes demonstrate IBs in their cells. Identification of infected individuals is critical for controlling the spread of the disease; however, the genetic divergence of reptarenaviruses complicates reverse transcription-PCR (RT-PCR)-based diagnostics.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Center for Clinical Studies
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Physiology
Physical Sciences > Ecology
Life Sciences > General Immunology and Microbiology
Life Sciences > Genetics
Health Sciences > Microbiology (medical)
Life Sciences > Cell Biology
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Infectious Diseases, Cell Biology, Microbiology (medical), Genetics, General Immunology and Microbiology, Ecology, Physiology
Language:English
Date:15 June 2023
Deposited On:21 Sep 2023 07:16
Last Modified:30 Oct 2024 02:35
Publisher:American Society for Microbiology
ISSN:2165-0497
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/spectrum.05065-22
PubMed ID:37212675
Other Identification Number:PMCID: PMC10269766
Project Information:
  • Funder: Academy of Finland
  • Grant ID:
  • Project Title:
  • Funder: Sigrid Juséliuksen Säätiö
  • Grant ID:
  • Project Title:
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  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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