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Reptarenavirus S Segment RNA Levels Correlate with the Presence of Inclusion Bodies and the Number of L Segments in Snakes with Reptarenavirus Infection—Lessons Learned from a Large Breeding Colony


Thiele, Tanja; Baggio, Francesca; Prähauser, Barbara; Ruiz Subira, Andres; Michalopoulou, Eleni; Kipar, Anja; Hetzel, Udo; Hepojoki, Jussi (2023). Reptarenavirus S Segment RNA Levels Correlate with the Presence of Inclusion Bodies and the Number of L Segments in Snakes with Reptarenavirus Infection—Lessons Learned from a Large Breeding Colony. Microbiology Spectrum, 11(3):e0506522.

Abstract

Boid inclusion body disease (BIBD) is caused by reptarenavirus infection, and while reptarenavirus nucleoprotein is the main component of the inclusion bodies (IBs) characteristic of BIBD, not all reptarenavirus-infected snakes demonstrate IBs in their cells. Identification of infected individuals is critical for controlling the spread of the disease; however, the genetic divergence of reptarenaviruses complicates reverse transcription-PCR (RT-PCR)-based diagnostics.

Abstract

Boid inclusion body disease (BIBD) is caused by reptarenavirus infection, and while reptarenavirus nucleoprotein is the main component of the inclusion bodies (IBs) characteristic of BIBD, not all reptarenavirus-infected snakes demonstrate IBs in their cells. Identification of infected individuals is critical for controlling the spread of the disease; however, the genetic divergence of reptarenaviruses complicates reverse transcription-PCR (RT-PCR)-based diagnostics.

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Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Center for Clinical Studies
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Physiology
Physical Sciences > Ecology
Life Sciences > General Immunology and Microbiology
Life Sciences > Genetics
Health Sciences > Microbiology (medical)
Life Sciences > Cell Biology
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Infectious Diseases, Cell Biology, Microbiology (medical), Genetics, General Immunology and Microbiology, Ecology, Physiology
Language:English
Date:15 June 2023
Deposited On:21 Sep 2023 07:16
Last Modified:29 Jun 2024 01:38
Publisher:American Society for Microbiology
ISSN:2165-0497
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/spectrum.05065-22
PubMed ID:37212675
Other Identification Number:PMCID: PMC10269766
Project Information:
  • : FunderAcademy of Finland
  • : Grant ID
  • : Project Title
  • : FunderSigrid Juséliuksen Säätiö
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)