Grathwohl, S A; Kälin, R E; Bolmont, T; Prokop, S; Winkelmann, G; Kaeser, S A; Odenthal, J; Radde, R; Eldh, T; Gandy, S; Aguzzi, A; Staufenbiel, M; Mathews, P M; Wolburg, H; Heppner, F L; Jucker, M (2009). Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience, 12(11):1361-1363.
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Language: | English |
| Date: | 2009 |
| Deposited On: | 09 Nov 2009 16:12 |
| Last Modified: | 17 Feb 2018 23:15 |
| Publisher: | Nature Publishing Group |
| ISSN: | 1097-6256 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1038/nn.2432 |
| PubMed ID: | 19838177 |
Grathwohl, S A