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Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John’s wort

Chauveau, Antoine; Treyer, Andrea; Geirnaert, Annelies; Bircher, Lea; Babst, Angela; Abegg, Vanessa Fabienne; Simões-Wüst, Ana Paula; Lacroix, Christophe; Potterat, Olivier; Hamburger, Matthias (2023). Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John’s wort. Biomedicine & Pharmacotherapy, 162:114652.

Abstract

Phytomedicines such as valerian and St. John's wort are widely used for the treatment of sleeping disorders, anxiety and mild depression. They are perceived as safe alternatives to synthetic drugs, but limited information is available on the intestinal absorption and interaction with human intestinal microbiota of pharmacologically relevant constituents valerenic acid in valerian, and hyperforin and hypericin in St. John's wort. The intestinal permeability of these compounds and the antidepressant and anxiolytic drugs citalopram and diazepam was investigated in the Caco-2 cell model with bidirectional transport experiments. In addition, interaction of compounds and herbal extracts with intestinal microbiota was evaluated in artificial human gut microbiota. Microbiota-mediated metabolisation of compounds was assessed, and bacterial viability and short-chain fatty acids (SCFA) production were measured in the presence of compounds or herbal extracts. Valerenic acid and hyperforin were highly permeable in Caco-2 cell monolayers. Hypericin showed low-to-moderate permeability. An active transport process was potentially involved in the transfer of valerenic acid. Hyperforin and hypericin were mainly transported through passive transcellular diffusion. All compounds were not metabolized over 24 h in the artificial gut microbiota. Microbial SCFA production and bacterial viability was not substantially impaired nor promoted by exposure to the compounds or herbal extracts.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Uncontrolled Keywords:Pharmacology, General Medicine
Language:English
Date:1 June 2023
Deposited On:24 Oct 2023 14:56
Last Modified:30 Oct 2024 02:36
Publisher:Elsevier
ISSN:0753-3322
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.biopha.2023.114652
PubMed ID:37027987
Project Information:
  • Funder: Eidgenössische Technische Hochschule Zürich
  • Grant ID:
  • Project Title:
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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