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Chemical mutagen testing on in vivo somatic mammalian cells


Schmid, Werner (1973). Chemical mutagen testing on in vivo somatic mammalian cells. Agents and Actions, 3(2):77-85.

Abstract

Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be taken into account; theoretical considerations should not override the actual observations. In the Appendix, technical details of the micronucleus test are given. Furthermore, some thoughts are expressed concerning cytogenetic testing on germ cells and embryos.

Abstract

Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be taken into account; theoretical considerations should not override the actual observations. In the Appendix, technical details of the micronucleus test are given. Furthermore, some thoughts are expressed concerning cytogenetic testing on germ cells and embryos.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Toxicology
Health Sciences > Pharmacology (medical)
Uncontrolled Keywords:Genetics, Genetics (clinical), Pharmacology (medical), Toxicology, Pharmacology, Immunology, Mammalian Cell, Germ Cell, Somatic Cell, Theoretical Consideration, Technical Detail
Language:English
Date:1 June 1973
Deposited On:25 Oct 2023 15:10
Last Modified:30 Mar 2024 04:48
Publisher:Birkhäuser
ISSN:0065-4299
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/bf01986538
PubMed ID:4125456
Other Identification Number:Corpus ID: 21663258