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An integrated vertex model of the mesoderm invagination during the embryonic development of Drosophila


Jiang, Jianfei; Aegerter, Christof M (2023). An integrated vertex model of the mesoderm invagination during the embryonic development of Drosophila. Journal of Theoretical Biology, 572:111581.

Abstract

The mesoderm invagination of the Drosophila embryo is known as an archetypal morphogenic process. To explore the roles of the active cellular forces and the regulation of these forces, we developed an integrated vertex model that combines the regulation of morphogen expression with cell movements and tissue mechanics. Our results suggest that a successful furrow formation requires an apical tension gradient, decreased basal tension, and increased lateral tension, which corresponds to apical constriction, basal expansion, and apicobasal shortening respectively. Our model also considers the mechanical feedback which leads to an ectopic twist expression with external compression as observed in experiments. Our model predicts that ectopic invagination could happen if an external compressive gradient is applied.

Abstract

The mesoderm invagination of the Drosophila embryo is known as an archetypal morphogenic process. To explore the roles of the active cellular forces and the regulation of these forces, we developed an integrated vertex model that combines the regulation of morphogen expression with cell movements and tissue mechanics. Our results suggest that a successful furrow formation requires an apical tension gradient, decreased basal tension, and increased lateral tension, which corresponds to apical constriction, basal expansion, and apicobasal shortening respectively. Our model also considers the mechanical feedback which leads to an ectopic twist expression with external compression as observed in experiments. Our model predicts that ectopic invagination could happen if an external compressive gradient is applied.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
Dewey Decimal Classification:530 Physics
Scopus Subject Areas:Physical Sciences > Statistics and Probability
Physical Sciences > Modeling and Simulation
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Life Sciences > General Immunology and Microbiology
Life Sciences > General Agricultural and Biological Sciences
Physical Sciences > Applied Mathematics
Uncontrolled Keywords:Applied Mathematics, General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Modeling and Simulation, General Medicine, Statistics and Probability
Language:English
Date:1 September 2023
Deposited On:15 Dec 2023 12:52
Last Modified:29 Jun 2024 01:40
Publisher:Elsevier
ISSN:0022-5193
Additional Information:Bereits als Working Paper in SSRN No. 4100997 erschienen: https://doi.org/10.2139/ssrn.4100997
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.jtbi.2023.111581
Related URLs:https://www.zora.uzh.ch/id/eprint/231010/
https://doi.org/10.2139/ssrn.4100997
PubMed ID:37481232
Project Information:
  • : FunderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • : Grant ID
  • : Project Title
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)