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Purging and accumulation of genetic load in conservation


Dussex, Nicolas; Morales, Hernán E; Grossen, Christine; Dalén, Love; van Oosterhout, Cock (2023). Purging and accumulation of genetic load in conservation. Trends in Ecology & Evolution, 38(10):961-969.

Abstract

Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.

Abstract

Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Scopus Subject Areas:Life Sciences > Ecology, Evolution, Behavior and Systematics
Uncontrolled Keywords:Ecology, Evolution, Behavior and Systematics
Language:English
Date:1 October 2023
Deposited On:20 Dec 2023 12:21
Last Modified:29 Jun 2024 01:41
Publisher:Elsevier
ISSN:0169-5347
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.tree.2023.05.008
PubMed ID:37344276
Project Information:
  • : FunderH2020
  • : Grant ID840519
  • : Project TitleGENDANGERED - Measuring GENomic diversity change over time in avian enDANGERED species
  • : FunderHorizon 2020
  • : Grant ID
  • : Project Title
  • : FunderHorizon 2020 Framework Programme
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)