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Physiologischer Weitblick ist gefragt. Hormone als Boten des Fetts zur langfristigen Modulation von Hunger und Sättigung


Lutz, Thomas A (2009). Physiologischer Weitblick ist gefragt. Hormone als Boten des Fetts zur langfristigen Modulation von Hunger und Sättigung. Aktuelle Ernährungsmedizin, 34(Supple):22-25.

Abstract

Leptin, insulin, and amylin are the so called adiposity signals; they inform the brain about the amount of fat deposited in the body. Leptin is produced and secreted directly by the fat cells, depending on the amount of body fat, whereas insulin and amylin originate from the pancreas. All 3 adiposity signals reduce food intake and increase energy release. Part of their effect is to increase the action of physiological satiation signals. If the amount of fat increases, however, leptin resistance often develops. This explains why, for example, the regulation mechanisms triggered by leptin do not work effectively in obese people. When used in combination, these hormones achieve a greater reduction in appetite and therefore body weight; they thus represent an interesting therapeutic option. Adiposity signals influence other bodily functions too. Sufficiently high concentrations of leptin and insulin are essential for successful reproduction. From a teleological perspective, this seems to make a lot of sense because reproduction (pregnancy, lactation) is a process that requires a lot of energy, so that sufficient energy reserves are beneficial.

Abstract

Leptin, insulin, and amylin are the so called adiposity signals; they inform the brain about the amount of fat deposited in the body. Leptin is produced and secreted directly by the fat cells, depending on the amount of body fat, whereas insulin and amylin originate from the pancreas. All 3 adiposity signals reduce food intake and increase energy release. Part of their effect is to increase the action of physiological satiation signals. If the amount of fat increases, however, leptin resistance often develops. This explains why, for example, the regulation mechanisms triggered by leptin do not work effectively in obese people. When used in combination, these hormones achieve a greater reduction in appetite and therefore body weight; they thus represent an interesting therapeutic option. Adiposity signals influence other bodily functions too. Sufficiently high concentrations of leptin and insulin are essential for successful reproduction. From a teleological perspective, this seems to make a lot of sense because reproduction (pregnancy, lactation) is a process that requires a lot of energy, so that sufficient energy reserves are beneficial.

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Additional indexing

Other titles:Wanted: Physiological VisionHormones as Adiposity Signals for the Long-Term Modulation of Hunger and Satiety
Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Medicine (miscellaneous)
Health Sciences > Nutrition and Dietetics
Language:German
Date:2009
Deposited On:09 Dec 2009 13:50
Last Modified:20 Jan 2021 16:35
Publisher:Thieme
ISSN:0341-0501
OA Status:Green
Publisher DOI:https://doi.org/10.1055/s-0028-1090136

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