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Group A Streptococcus strains causing meningitis without distinct invasive phenotype

Abstract

Group A streptococcal (GAS; aka Streptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from five cases of meningitis to otitis and colonizing isolates. We did not observe differences in adherence to and invasion of human brain microvascular endothelial cells, virulence factors activity, or barrier disruption. Whole genome sequencing did not reveal particular invasiveness traits. Most patients previously suffered from otitis media suggesting that meningitis likely resulted from a continuous spread of the infection rather than being attributable to changes in the pathogen's virulence.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Intensive Care Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Microbiology
Uncontrolled Keywords:Microbiology
Language:English
Date:February 2024
Deposited On:11 Jan 2024 12:39
Last Modified:30 Oct 2024 02:40
Publisher:Wiley Open Access
ISSN:2045-8827
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/mbo3.1394
Project Information:
  • Funder: Vontobel-Stiftung
  • Grant ID:
  • Project Title:
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  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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