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Consensus position statement on advancing the standardised reporting of infection events in immunocompromised patients


Teh, Benjamin W; Mikulska, Malgorzata; Averbuch, Dina; de la Camara, Rafael; Hirsch, Hans H; Akova, Murat; Ostrosky-Zeichner, Luis; Baddley, John W; Tan, Ban Hock; Mularoni, Alessandra; Subramanian, Aruna K; La Hoz, Ricardo M; Marinelli, Tina; Boan, Peter; Aguado, Jose Maria; Grossi, Paolo A; Maertens, Johan; Mueller, Nicolas J; Slavin, Monica A (2024). Consensus position statement on advancing the standardised reporting of infection events in immunocompromised patients. Lancet Infectious Diseases, 24(1):e59-e68.

Abstract

Patients can be immunocompromised from a diverse range of disease and treatment factors, including malignancies, autoimmune disorders and their treatments, and organ and stem-cell transplantation. Infections are a leading cause of morbidity and mortality in immunocompromised patients, and the disease treatment landscape is continually evolving. Despite being a critical but preventable and curable adverse event, the reporting of infection events in randomised trials lacks sufficient detail while inconsistency of categorisation and definition of infections in observational and registry studies limits comparability and future pooling of data. A core reporting dataset consisting of category, site, severity, organism, and endpoints was developed as a minimum standard for reporting of infection events in immunocompromised patients across study types. Further additional information is recommended depending on study type. The standardised reporting of infectious events and attributable complications in immunocompromised patients will improve diagnostic, treatment, and prevention approaches and facilitate future research in this patient group.

Abstract

Patients can be immunocompromised from a diverse range of disease and treatment factors, including malignancies, autoimmune disorders and their treatments, and organ and stem-cell transplantation. Infections are a leading cause of morbidity and mortality in immunocompromised patients, and the disease treatment landscape is continually evolving. Despite being a critical but preventable and curable adverse event, the reporting of infection events in randomised trials lacks sufficient detail while inconsistency of categorisation and definition of infections in observational and registry studies limits comparability and future pooling of data. A core reporting dataset consisting of category, site, severity, organism, and endpoints was developed as a minimum standard for reporting of infection events in immunocompromised patients across study types. Further additional information is recommended depending on study type. The standardised reporting of infectious events and attributable complications in immunocompromised patients will improve diagnostic, treatment, and prevention approaches and facilitate future research in this patient group.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Infectious Diseases
Language:English
Date:January 2024
Deposited On:15 Jan 2024 16:26
Last Modified:30 Jun 2024 01:37
Publisher:Elsevier
ISSN:1473-3099
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/S1473-3099(23)00377-8
PubMed ID:37683684