Cribiú, R; Jäger, C; Nevado, C (2009). Syntheses and biological evaluation of iriomoteolide 3a and analogues. Angewandte Chemie Internationale Edition, 48(46):8780-8783.
Metathesis on stage: A combined cross-metathesis (CM)/ring-closing metathesis (RCM) approach has led to the stereocontrolled synthesis of iriomoteolide 3a, a smaller but equally cytotoxic congener of amphidinolides. Chemical editing of the molecule has provided non-natural analogues which have comparable anticancer activity to that of the natural product, thereby allowing the iriomoteolides to be used as probe molecules in chemical biology.
Metathesis on stage: A combined cross-metathesis (CM)/ring-closing metathesis (RCM) approach has led to the stereocontrolled synthesis of iriomoteolide 3a, a smaller but equally cytotoxic congener of amphidinolides. Chemical editing of the molecule has provided non-natural analogues which have comparable anticancer activity to that of the natural product, thereby allowing the iriomoteolides to be used as probe molecules in chemical biology.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Language: | English |
| Date: | 2009 |
| Deposited On: | 15 Jan 2010 10:46 |
| Last Modified: | 17 Feb 2018 23:26 |
| Publisher: | Wiley-VCH Verlag |
| ISSN: | 1433-7851 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/anie.200903379 |
Cribiú, R