Header

UZH-Logo

Maintenance Infos

Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol-Sensitive Release Platform


Studer, Tetiana; Morina, Daria; Shchelik, Inga S; Gademann, Karl (2023). Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol-Sensitive Release Platform. Chemistry, 29(26):e202203913.

Abstract

This study reports on the design and engineering of biohybrid microswimmers exploiting a thiol-mediated self-immolative antibiotic release strategy. The design features a covalent attachment of a vancomycin conjugate via a disulfide-based linker to the surface of the microalgae Chlamydomonas reinhardtii. The antibiotic release from the surface of these biohybrids was triggered by the addition of a thiol-based reducing agent, and, subsequently, the inhibition of bacterial growth was observed for Bacillus subtilis and Staphylococcus aureus. These engineered microbots represent the first example of a microalgae-based drug delivery system with a thiol-mediated, reductive release of an antibiotic drug.

Abstract

This study reports on the design and engineering of biohybrid microswimmers exploiting a thiol-mediated self-immolative antibiotic release strategy. The design features a covalent attachment of a vancomycin conjugate via a disulfide-based linker to the surface of the microalgae Chlamydomonas reinhardtii. The antibiotic release from the surface of these biohybrids was triggered by the addition of a thiol-based reducing agent, and, subsequently, the inhibition of bacterial growth was observed for Bacillus subtilis and Staphylococcus aureus. These engineered microbots represent the first example of a microalgae-based drug delivery system with a thiol-mediated, reductive release of an antibiotic drug.

Statistics

Citations

Dimensions.ai Metrics
2 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 18 Feb 2024
2 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > General Chemistry
Physical Sciences > Organic Chemistry
Uncontrolled Keywords:General Chemistry, Catalysis, Organic Chemistry
Language:English
Date:May 2023
Deposited On:18 Feb 2024 15:24
Last Modified:30 Jun 2024 01:37
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0947-6539
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1002/chem.202203913
PubMed ID:36757109
Project Information:
  • : FunderSNSF
  • : Grant ID182043
  • : Project TitleMechanism-Based Design, Synthesis, Biological Evaluation, and Delivery of Next-Generation Antibiotics
  • : FunderSNSF
  • : Grant ID212603
  • : Project TitleMechanism-Based Design, Synthesis, and Biological Evaluation of Next-Generation Antibiotics
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)