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Osteopontin levels correlate with severity of diabetic cardiomyopathy in early stage of diabetes


Abstract

Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.

Abstract

Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Molecular Cardiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Internal Medicine
Health Sciences > Endocrinology, Diabetes and Metabolism
Life Sciences > Endocrinology
Uncontrolled Keywords:Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine
Language:English
Date:September 2023
Deposited On:30 Jan 2024 14:08
Last Modified:30 Jun 2024 01:38
Publisher:Elsevier
ISSN:0168-8227
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.diabres.2023.110885
PubMed ID:37598938
Project Information:
  • : FunderDepartment of Internal Medicine, University of Utah
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  • : FunderUniversità degli Studi di Genova
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