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The pathogenic and colonization potential of Candida africana


Kosmala, Daria; Sertour, Natacha; Fróis Martins, Ricardo; Spaggiari, Luca; Ardizzoni, Andrea; LeibundGut-Landmann, Salomé; Pericolini, Eva; Bougnoux, Marie-Elisabeth; d’Enfert, Christophe; Legrand, Mélanie (2024). The pathogenic and colonization potential of Candida africana. Microbes and infection, 26(1-2):105230.

Abstract

The Candida albicans population displays high genetic diversity illustrated by 18-well differentiated genetic clusters. Cluster 13, also known as Candida africana, is an outlying cluster and includes strains first described as atypical C. albicans isolates of vaginal origin, showing apparent tropism for the female genital tract. In our study, we combined in vitro, and in vivo models to explore the colonization and pathogenic potential of C. africana. We report that C. africana has similar fitness to C. albicans when it comes to colonization of the oral and vaginal mucosa, however it has decreased fitness in gastro-intestinal colonization and systemic infection. Interestingly, despite high population homogeneity, our in vitro data highlighted for the first time a variability in terms of growth rate, biofilm formation and filamentation properties between C. africana strains. Overall, our data lays the foundations for exploring specific features of C. africana that might contribute to its apparent niche restriction.

Abstract

The Candida albicans population displays high genetic diversity illustrated by 18-well differentiated genetic clusters. Cluster 13, also known as Candida africana, is an outlying cluster and includes strains first described as atypical C. albicans isolates of vaginal origin, showing apparent tropism for the female genital tract. In our study, we combined in vitro, and in vivo models to explore the colonization and pathogenic potential of C. africana. We report that C. africana has similar fitness to C. albicans when it comes to colonization of the oral and vaginal mucosa, however it has decreased fitness in gastro-intestinal colonization and systemic infection. Interestingly, despite high population homogeneity, our in vitro data highlighted for the first time a variability in terms of growth rate, biofilm formation and filamentation properties between C. africana strains. Overall, our data lays the foundations for exploring specific features of C. africana that might contribute to its apparent niche restriction.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Immunology
04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Microbiology
Life Sciences > Immunology
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Infectious Diseases, Immunology, Microbiology
Language:English
Date:1 January 2024
Deposited On:06 Feb 2024 17:43
Last Modified:30 Jun 2024 01:38
Publisher:Elsevier
ISSN:1286-4579
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.micinf.2023.105230
PubMed ID:37734535
Project Information:
  • : FunderGuizhou Institute of Technology
  • : Grant ID
  • : Project Title
  • : FunderH2020
  • : Grant ID812969
  • : Project TitleFunHoMic - Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections
  • : FunderHorizon 2020
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)