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Immediate stabilization of pedicle screws: Preclinical pilot study of polymer-augmented pedicle screws

de Wild, Michael; Zimmermann, Simon; Klein, Karina; Steffen, Thomas; Schlottig, Falko; Hasler, Carol; von Rechenberg, Brigitte (2023). Immediate stabilization of pedicle screws: Preclinical pilot study of polymer-augmented pedicle screws. Current Directions in Biomedical Engineering, 9(1):13-16.

Abstract

This study was designed as proof of principle and safety test of the novel technique, the Immediate Stabilization System (ISS). The technique is designed to immediately stabilize polymer-a ugmented pedicle screws (PAS) in deficient bone and avoid complications of loosening pedicle screws at the bone-screw interface, especially in osteoporotic patients. A polymer sleeve was designed as augmentation to improve screw anchorage after drilling the screw hole. By applying ultrasonic energy, the polymeric tube was moldedinto the pores of the host bone forming a strong and uniform bond with the adjacent bone. The original screw was then implanted into the denser bony environment leading to an enhanced immediate stability. The ISS-treated implants were compared to conventionally placed pedicle screws in ex-vivocadaver bones (2 sheep spines, n = 6 implants per spine, total 12 screws) and in-vivo in a spinal sheep model (Swiss alpine sheep, n = 5, 4 implants per animal, total 20 screws). The primary stability of ISS-treated pedicle screws was increased in ex-vivo bone ( +24% insertion torque (IT)) and in-vivo(+32.9% IT) in sheep spine. Removal torque (RT) was lower in the in PAS tested for 8 weeks in -vivo. The ISS technology demonstrated improved anchorage of pedicle screws in ex-vivocadaver bones as well as in-vivo studies in sheep spine.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease

05 Vetsuisse Faculty > Center for Applied Biotechnology and Molecular Medicine
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Physical Sciences > Biomedical Engineering
Language:English
Date:20 September 2023
Deposited On:18 Feb 2024 15:22
Last Modified:29 Sep 2024 03:36
Publisher:De Gruyter
ISSN:2364-5504
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1515/cdbme-2023-1004
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  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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