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History information emerges in the cortex during learning


Marmor, Odeya; Pollak, Yael; Doron, Chen; Helmchen, Fritjof; Gilad, Ariel (2023). History information emerges in the cortex during learning. eLife, 12:e83702.

Abstract

We learn from our experience but the underlying neuronal mechanisms incorporating past information to facilitate learning is relatively unknown. Specifically, which cortical areas encode history-related information and how is this information modulated across learning? To study the relationship between history and learning, we continuously imaged cortex-wide calcium dynamics as mice learn to use their whiskers to discriminate between two different textures. We mainly focused on comparing the same trial type with different trial history, that is, a different preceding trial. We found trial history information in barrel cortex (BC) during stimulus presentation. Importantly, trial history in BC emerged only as the mouse learned the task. Next, we also found learning-dependent trial history information in rostrolateral (RL) association cortex that emerges before stimulus presentation, preceding activity in BC. Trial history was also encoded in other cortical areas and was not related to differences in body movements. Interestingly, a binary classifier could discriminate trial history at the single trial level just as well as current information both in BC and RL. These findings suggest that past experience emerges in the cortex around the time of learning, starting from higher-order association area RL and propagating down (i.e., top-down projection) to lower-order BC where it can be integrated with incoming sensory information. This integration between the past and present may facilitate learning.

Abstract

We learn from our experience but the underlying neuronal mechanisms incorporating past information to facilitate learning is relatively unknown. Specifically, which cortical areas encode history-related information and how is this information modulated across learning? To study the relationship between history and learning, we continuously imaged cortex-wide calcium dynamics as mice learn to use their whiskers to discriminate between two different textures. We mainly focused on comparing the same trial type with different trial history, that is, a different preceding trial. We found trial history information in barrel cortex (BC) during stimulus presentation. Importantly, trial history in BC emerged only as the mouse learned the task. Next, we also found learning-dependent trial history information in rostrolateral (RL) association cortex that emerges before stimulus presentation, preceding activity in BC. Trial history was also encoded in other cortical areas and was not related to differences in body movements. Interestingly, a binary classifier could discriminate trial history at the single trial level just as well as current information both in BC and RL. These findings suggest that past experience emerges in the cortex around the time of learning, starting from higher-order association area RL and propagating down (i.e., top-down projection) to lower-order BC where it can be integrated with incoming sensory information. This integration between the past and present may facilitate learning.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
04 Faculty of Medicine > Neuroscience Center Zurich
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Life Sciences > General Immunology and Microbiology
Uncontrolled Keywords:General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, General Neuroscience; barrel cortex; history; learning; mouse; neuroscience; posterior parietal cortex; rostrolateral cortex; texture discrimination; wide-field imaging
Language:English
Date:3 November 2023
Deposited On:15 Feb 2024 08:55
Last Modified:30 Jun 2024 03:34
Publisher:eLife Sciences Publications Ltd.
ISSN:2050-084X
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.7554/elife.83702
PubMed ID:37921842
Project Information:
  • : FunderH2020
  • : Grant ID659719
  • : Project TitleAG-GF - Behavior-dependent interactions between frontal and somatosensory cortices
  • : FunderHebrew University of Jerusalem, Start up grant
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)