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MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections


Roehrig, Christian; Huemer, Markus; Lorgé, Dominique; Arn, Fabienne; Heinrich, Nadine; Selvakumar, Lavanja; Gasser, Lynn; Hauswirth, Patrick; Chang, Chun-Chi; Schweizer, Tiziano A; Eichenseher, Fritz; Lehmann, Steffi; Zinkernagel, Annelies S; Schmelcher, Mathias (2024). MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections. mBio, 15(2):e0254023.

Abstract

One of the most pressing challenges of our era is the rising occurrence of bacteria that are resistant to antibiotics. Staphylococci are prominent pathogens in humans, which have developed multiple strategies to evade the effects of antibiotics. Infections caused by these bacteria have resulted in a high burden on the health care system and a significant loss of lives. In this study, we have successfully engineered lytic enzymes that exhibit an extraordinary ability to eradicate staphylococci. Our findings substantiate the importance of meticulous lead candidate selection to identify therapeutically promising peptidoglycan hydrolases with unprecedented activity. Hence, they offer a promising new avenue for treating staphylococcal infections.

Abstract

One of the most pressing challenges of our era is the rising occurrence of bacteria that are resistant to antibiotics. Staphylococci are prominent pathogens in humans, which have developed multiple strategies to evade the effects of antibiotics. Infections caused by these bacteria have resulted in a high burden on the health care system and a significant loss of lives. In this study, we have successfully engineered lytic enzymes that exhibit an extraordinary ability to eradicate staphylococci. Our findings substantiate the importance of meticulous lead candidate selection to identify therapeutically promising peptidoglycan hydrolases with unprecedented activity. Hence, they offer a promising new avenue for treating staphylococcal infections.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Microbiology
Life Sciences > Virology
Uncontrolled Keywords:Virology, Microbiology
Language:English
Date:14 February 2024
Deposited On:27 Mar 2024 11:02
Last Modified:30 Jun 2024 03:42
Publisher:American Society for Microbiology
ISSN:2150-7511
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/mbio.02540-23
PubMed ID:38275913
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)