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Effects of prednisolone on 1,2-O-dilauryl-rac-glycero glutaricacid-(60-methylresorufin) ester-lipase activity and pancreaticlipase immunoreactivity in healthy cats


Pacheva, Militsa; Brugger, Daniel; Riond, Barbara; Dennler, Matthias; Kook, Peter H (2024). Effects of prednisolone on 1,2-O-dilauryl-rac-glycero glutaricacid-(60-methylresorufin) ester-lipase activity and pancreaticlipase immunoreactivity in healthy cats. Journal of Veterinary Internal Medicine, 38(3):1370-1376.

Abstract

Background:
Corticosteroids are among the most commonly used drugs in cats andare increasingly discussed as a treatment for feline pancreatitis. However, its effectson serum lipase in healthy cats remain unknown.
Objectives:
To evaluate the effects of prednisolone on serum lipase activity and pan-creatic lipase immunoreactivity (PLI) in cats.
Animals:
Seven clinically healthy colony cats, aged 4 to 7 years, with unremarkableCBC/biochemistry panel were studied.Methods:Prospective study: Prednisolone (1.1-1.5 mg/kg, median 1.28 mg/kg PO)was given daily for 7 consecutive days. Lipase activity (LIPC Roche; RI, 8-26 U/L) andPLI (Spec fPL; RI, 0-3.5μg/L) were determined at day 1 before first treatment and atdays 2, 3, 8, 10, and 14. Cats were examined daily. An a priori power analysis indi-cated that 6 cats were needed to find a biological relevant effect at 1-β=0.8. Statis-tical analyses comprised the Friedman test, random intercept regression, andrepeated-measures linear regression.
Results:
Median (range) day 1 lipase activities and PLI were 22 U/L (14-52 U/L) and3.2μg/L (2.3-15.7μg/L). One cat with abnormally high lipase activity (52 U/L) andPLI (15.7μg/L) at day 1 continued having elevated lipase activities and PLI through-out the study. Lipase activities and PLI concentrations did not differ significantlyamong time points regardless of whether the cat with elevated values was includedor not. All cats remained healthy throughout the study.
Conclusions and Clinical Importance:
Administration of prednisolone in anti-inflammatory doses does not significantly increase serum lipase activity and PLI concentration.

Abstract

Background:
Corticosteroids are among the most commonly used drugs in cats andare increasingly discussed as a treatment for feline pancreatitis. However, its effectson serum lipase in healthy cats remain unknown.
Objectives:
To evaluate the effects of prednisolone on serum lipase activity and pan-creatic lipase immunoreactivity (PLI) in cats.
Animals:
Seven clinically healthy colony cats, aged 4 to 7 years, with unremarkableCBC/biochemistry panel were studied.Methods:Prospective study: Prednisolone (1.1-1.5 mg/kg, median 1.28 mg/kg PO)was given daily for 7 consecutive days. Lipase activity (LIPC Roche; RI, 8-26 U/L) andPLI (Spec fPL; RI, 0-3.5μg/L) were determined at day 1 before first treatment and atdays 2, 3, 8, 10, and 14. Cats were examined daily. An a priori power analysis indi-cated that 6 cats were needed to find a biological relevant effect at 1-β=0.8. Statis-tical analyses comprised the Friedman test, random intercept regression, andrepeated-measures linear regression.
Results:
Median (range) day 1 lipase activities and PLI were 22 U/L (14-52 U/L) and3.2μg/L (2.3-15.7μg/L). One cat with abnormally high lipase activity (52 U/L) andPLI (15.7μg/L) at day 1 continued having elevated lipase activities and PLI through-out the study. Lipase activities and PLI concentrations did not differ significantlyamong time points regardless of whether the cat with elevated values was includedor not. All cats remained healthy throughout the study.
Conclusions and Clinical Importance:
Administration of prednisolone in anti-inflammatory doses does not significantly increase serum lipase activity and PLI concentration.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Animal Nutrition
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Health Sciences > General Veterinary
Language:English
Date:1 May 2024
Deposited On:25 Apr 2024 10:29
Last Modified:18 May 2024 01:06
Publisher:Wiley Open Access
ISSN:0891-6640
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jvim.17042
PubMed ID:38485220
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)