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Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods

Lösle, Martina; Grund, K E; Duckworth-Mothes, B (2024). Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods. Journal of Molecular Medicine, 102(8):1009-1013.

Abstract

In this work, for the first time, the specific impedances of various injection solutions as well as the surface and tissue impedance after injection of these solutions were analyzed and compared regarding the radio-frequency surgical cutting process. The impedances of 0.9% NaCl, 4% gelatine, 6% hydroxyethyl starch, 10% glycerol/5% fructose, 10% glucose, 5% and 20% albumin, blood, and blood plasma as well as aqua destillata have been tested in vitro. Even if EMR and ESD are routinely used in clinical practice, there is so far no easy, fast, and safe method to remove larger lesions en bloc. We show that the impedance of the injected solution shows to be a crucial factor for safe removal, especially of larger lesions (Ø > 20 mm) and more importantly in accordance with the requirements of oncology and pathology. KEY MESSAGES: Impedance is playing a crucial factor in the radio-frequency (RF)-surgery. With a higher Impedance there will be less current necessary to reach the aimed voltage. Injection solution Aqua destillata and 10% Glucose, show significantly higher Impedances. Higher impedances lead to less surgical related complications. Minor changes in existing method to improve patent safety.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Laboratory Animal Science
05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Laboratory Animal Science
Dewey Decimal Classification:590 Animals (Zoology)
610 Medicine & health
570 Life sciences; biology
Language:English
Date:1 August 2024
Deposited On:05 Jun 2024 18:51
Last Modified:29 Apr 2025 01:37
Publisher:Springer
ISSN:0946-2716
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1007/s00109-024-02457-1
PubMed ID:38829423
Project Information:
  • Funder: University of Zurich
  • Grant ID:
  • Project Title:
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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