Abstract
A two-step reaction cascade is applied to the sequence-specific detection of single-stranded DNA, including analyte-triggered re-activation of apo-aldolase by its cofactor Zn(2+) and catalytic conversion of a chromophore.
Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade
Graf, Nora; Kassube, Susanne A; Krämer, Roland (2008). Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade. Bioorganic & Medicinal Chemistry Letters, 18(17):4786-4788.
Additional indexing
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Molecular Biology Life Sciences > Pharmaceutical Science Life Sciences > Drug Discovery Life Sciences > Clinical Biochemistry Physical Sciences > Organic Chemistry |
| Language: | English |
| Date: | 1 September 2008 |
| Deposited On: | 26 Sep 2024 11:24 |
| Last Modified: | 28 Feb 2025 02:36 |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.bmcl.2008.07.102 |
| PubMed ID: | 18701280 |
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Graf, Nora