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Re-evaluating human MTL in working memory: insights from intracranial recordings

Li, Jin; Cao, Dan; Li, Wenlu; Sarnthein, Johannes; Jiang, Tianzi (2024). Re-evaluating human MTL in working memory: insights from intracranial recordings. Trends in Cognitive Sciences, 28(12):1132-1144.

Abstract

The study of human working memory (WM) holds significant importance in neuroscience; yet, exploring the role of the medial temporal lobe (MTL) in WM has been limited by the technological constraints of noninvasive methods. Recent advancements in human intracranial neural recordings have indicated the involvement of the MTL in WM processes. These recordings show that different regions of the MTL are involved in distinct aspects of WM processing and also dynamically interact with each other and the broader brain network. These findings support incorporating the MTL into models of the neural basis of WM. This integration can better reflect the complex neural mechanisms underlying WM and enhance our understanding of WM's flexibility, adaptability, and precision.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Social Sciences & Humanities > Experimental and Cognitive Psychology
Life Sciences > Cognitive Neuroscience
Uncontrolled Keywords:functional specialization; inter-regional interaction; intracranial EEG (iEEG); medial temporal lobe (MTL); single-neuron activity (SUA); working memory (WM)
Language:English
Date:1 December 2024
Deposited On:25 Sep 2024 08:09
Last Modified:28 Feb 2025 02:37
Publisher:Elsevier
ISSN:1364-6613
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.tics.2024.07.008
PubMed ID:39174398

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