Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor

Abstract

N.J. Mueller, M. Weisser, T. Fehr, R.P. Wüthrich, B. Müllhaupt, R. Lehmann, A. Imhof, J.-D. Aubert, M. Genoni, R. Kunz, M. Weber, J. Steiger. Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor. Transpl Infect Dis 2009. All rights reserved Abstract: The growing need for organs and the scarcity of donors has resulted in an increased use of extended criteria donors. We report a case where a recipient of a cardiac graft was used as an organ donor. Death of the recipient occurred 9 days after transplantation and was attributed to presumed cerebral hemorrhage, which post mortem was diagnosed as invasive aspergillosis of the brain. One recipient of a kidney transplant lost the graft due to infection with Aspergillus fumigatus, whereas prompt initiation of therapy successfully prevented disseminated aspergillosis in the other recipients. Despite the pressure to extend the use of organs by lowering the acceptance criteria, organs should only be accepted if the cause of death of the donors is unequivocally explained.