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Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma


Bihl, F; Berger, C; Chisholm, J V; Henry, L M; Bertisch, B; Trojan, A; Nadal, D; Speck, R F; Flepp, M; Brander, C; Mueller, N J (2009). Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma. AIDS, 23(14):1918-1922.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:19 Jan 2010 09:05
Last Modified:24 Nov 2018 17:37
Publisher:Lippincott Wiliams & Wilkins
ISSN:0269-9370
Additional Information:This is a non-final version of an article published in final form in AIDS, 23(14):1918-1922.
OA Status:Green
Publisher DOI:https://doi.org/10.1097/QAD.0b013e3283300a91
PubMed ID:19609199

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