Aicher, W K; Pap, T; Gay, S (2008). Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten. Zeitschrift für Rheumatologie, 67(1):59-61.
Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.
Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.
| Other titles: | Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients |
|---|---|
| Item Type: | Journal Article, refereed, original work |
| Communities & Collections: | 04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Rheumatology |
| Language: | German |
| Date: | 2008 |
| Deposited On: | 05 Aug 2008 09:10 |
| Last Modified: | 01 Nov 2023 02:44 |
| Publisher: | Springer |
| ISSN: | 0340-1855 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1007/s00393-008-0261-1 |
| PubMed ID: | 18214499 |
Aicher, W K