Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow

Onai, N; Manz, M G; Schmid, M A (2010). Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. In: Naik, S H. Dendritic Cell Protocols. United States: Springer / Humana Press, 195-203.

Abstract

In the steady-state lymphoid organ, dendritic cells (DCs) are classified into two major subsets, plasmacytoid DC (pDC) and conventional DC (cDC). A standing question was whether a common progenitor for plasmacytoid and conventional dendritic cells exists during the sequential differentiation from hematopoietic stem cells to dendritic cells. We have recently identified such a common clonogenic plasmacytoid and dendritic cell progenitor (CDP) from mouse bone marrow using antibodies for c-kit, Flt3, and M-CSFR. CDPs generated almost exclusively pDC and cDC in vitro and upon transfer in irradiated and steady-state mice in vivo. Single-cell analysis revealed the existence of clonal progenitors giving rise to both pDC and cDC within the CDP population. Thus, these results prove the existence of a common developmental pathway for at least some pDCs and cDCs in lymphoid organs in vivo.

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Biology
Life Sciences > Genetics
Language:English
Date:2010
Deposited On:02 Mar 2010 14:15
Last Modified:09 Jul 2025 03:43
Publisher:Springer / Humana Press
Series Name:Methods in Molecular Biology
Number:Volume 595
ISSN:1064-3745 (P) 1940-6029 (E)
ISBN:978-1-60761-420-3 (P) 978-1-60761-421-0 (E)
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-1-60761-421-0_13
PubMed ID:19941114
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
11 citations in Web of Science®
13 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications