Legrand, N; Ploss, A; Balling, R; Becker, P D; Borsotti, C; Brezillon, N; Debarry, J; De Jong, Y; Deng, H; Di Santo, J P; Eisenbarth, S; Eynon, E; Flavell, R A; Guzman, C A; Huntington, N D; Kremsdorf, D; Manns, M P; Manz, M G; Mention, J J; Ott, M; Rathinam, C; Rice, C M; Rongvaux, A; Stevens, S; Spits, H; Strick-Marchand, H; Takizawa, H; van Lent, A U; Wang, C; Weijer, K; Willinger, T; Ziegler, P (2009). Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host & Microbe, 6(1):5-9.
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Language: | English |
| Date: | 23 July 2009 |
| Deposited On: | 02 Mar 2010 14:35 |
| Last Modified: | 24 Sep 2019 16:38 |
| Publisher: | Elsevier |
| ISSN: | 1931-3128 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.chom.2009.06.006 |
| PubMed ID: | 19616761 |
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Legrand, N