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Tissue-engineered trachea: History, problems and the future


Tan, Q; Steiner, R; Hoerstrup, S P; Weder, W (2006). Tissue-engineered trachea: History, problems and the future. European Journal of Cardio-Thoracic Surgery, 30(5):782-786.

Abstract

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.

Abstract

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2006
Deposited On:24 Mar 2010 07:14
Last Modified:01 Oct 2019 11:27
Publisher:Elsevier
ISSN:1010-7940
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.ejcts.2006.08.023
PubMed ID:17011786

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