Microlensing observations toward M31 are a powerful tool for the study of the dark matter population in the form of MACHOs both in the Galaxy and the M31 halos, a still unresolved issue, as well as for the analysis of the characteristics of the M31 luminous populations. In this work, we present the second-year results of our pixel lensing campaign carried out toward M31 using the 152 cm Cassini telescope in Loiano. We have established an automatic pipeline for the detection and the characterization of microlensing variations. We have carried out a complete simulation of the experiment and evaluated the expected signal, including an analysis of the efficiency of our pipeline. As a result, we select 1-2 candidate microlensing events (according to different selection criteria). This output is in agreement with the expected rate of M31 self-lensing events. However, the statistics are still too low to draw definitive conclusions on MACHO lensing.